Diabetes, therefore they are very important markers for islet autoimmunity and play an essential role in prediction, prevention, and clinical practice for diagnosis and treatment for type 1 diabetes.HLA is a well know major susceptible gene marker for type 1 diabetes. With early detection of islet autoantibodies and HLA genetic analysis, it will help to study natural history of the disease and to try understanding underlying mechanism of interaction between environmental aspects and immune system/genetics which will be important for the study of etiology of type 1 diabetes. Dr. Yu himself developed and set up all these autoantibody assays in the current laboratory and recently he has developed a new assay method for these autoantibody assays demonstrated more sensitive and more disease specific which has been patented through university
tech-transfer office and it will be used as a pilot study in NIH/NIDDK leaded national/international type 1 diabetes clinical trials for autoantibody screening. Dr. Yu also has studies on other related autoimmune diseases like Celiac disease through transglutaminase autoantibody study and Addison’s disease through 21-Hydroxilase autoantibody study. Dr.Yu does consulting about integrative east and west medicine for dibetis with Dr.Hou in EWMI now.